The aircraft collided with trees and terrain while on an instrument approach to Oscoda-Wurtsmith Airport (OSC), Oscoda, Michigan. The airline transport pilot was fatally injured, and the airplane was destroyed by impact forces and a post-impact fire. The airplane was registered to Kalitta Equipment LLC, and was operated by Kalitta Charters as a Title14 Code of Federal Regulations (CFR) Part 91 positioning flight. Instrument meteorological conditions prevailed at the accident site at the time of the accident, and an instrument flight rules (IFR) flight plan was filed for the flight which originated from Willow Run Airport (YIP), Ypsilanti, Michigan, about 0513. According to Kalitta personnel, the pilot was flying to OSC to pick up passengers and subsequently fly them to Memphis, Tennessee. The airplane departed YIP about 0513 and climbed to a cruise altitude of about 13,500 ft. The airplane en route airspeed was about 250 knots. At 0537, when the airplane was about 85 miles south of OSC, it began its initial descent. At 0548, the airplane was vectored to the right to intercept the final approach course and was cleared for the VOR runway 6 approach at OSC. The last radar return was at 0550 and indicated that the airplane was at an altitude of 2,200 ft and 8.1 miles from the runway threshold. It impacted terrain 4.6 miles past this point, about 3.5 miles from the runway threshold. According to the VOR runway 6 approach procedure, an altitude of 2,500 ft (or higher) is flown during the procedure turn. If the OSC altimeter setting is used, descent is made to 1,660 feet to Dogsy intersection, and then to 1,100 feet, the minimum descent altitude (MDA) to Au Sable (ASP) intersection. When the airplane failed to arrive at the airport as scheduled, Kalitta officials notified the Federal Aviation Administration. The wreckage was subsequently located about 1030.